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Xi Huang

Xi Huang

Nanjing University of Chinese Medicine, China

Title: Gut-brain signals following stress: updates from integration by Shugan

Biography

Biography: Xi Huang

Abstract

Considerably clinical and experimental evidences accumulated show bidirectionally interactions between FGIDs(functional gastrointestinal disorders) and depression following stress via gut-brain signals including α2-AR, ghrelin(Ghr), IL-1, NO and kynurenine(AGINK). All AGINK signals have not been pharmacodynamically integrated by simultaneous antidepressants and mediating gut motor(A&M) because there are no A&M agents. In fact, such A&M effects by Shugan of TCM formulae often occur separately in different publications. We aim to elucidate and integrate gut-brain signals following stress via evidences from  literature  and  simultaneous  A&M compounds from Shugan’s herbs in our previous and recent studies. Available conclusions include: 1)AGINK are better gut-brain signals than other molecules, supported by more evidences  separately involved in depression and FGIDs. Of these, no one had been integrated by  simultaneous A&M pharmacology before 2013; 2)Such action has been theoretically described for thousands of years and separately occurred for hundreds of years among several decades of TCM formulae and their compounds. However, no one had been tested its synchronous A&M efficacy before; 3) For the first time: via mediating HPA axis hormones, 5-HT/NA/ DA(involved in antidepressants) and Ghr(involved in prokinetic) concentration, concurrent A&M(the latter action  is prokinetic) efficacy induced by Chaihu-shugan-san(CSS) formula and its absorbed compound ferulic acid happened when compared by us in 2011. Such antidepressant and prokinetic(A&P) action also occur after oral meranzin hydrate(MH), hesperidin, peoniflorin and Senkyunolide to rat swept forcedly in our recent works, mediating by IL-1, 10β, oxidation stress, kynurenine and BDNF/p-mTOR, specially AMPA-ERK1/2-BDNF pathway for fast antidepressant without side effect similar to Ketamine. 4)α2-AR of disorder in gut-brain axis following FST to rat was integrated by MH-produced simultaneous A&P pharmacology, suggesting first  shared molecular  of A&P. Second shared molecular is Ghr. Shugan- and A&P-integrated shared molecules highlight personalized overlap of depression and FGIDs, suggesting potentially clinical biomarker in future.