Juan C Carril
Euro Espes Biomedical Research Center, Spain
Title: Nutrigenomic Card: The Nutrigenetic Risk Test
Biography
Biography: Juan C Carril
Abstract
Obesity is a complex disease in which hereditary predisposition, alimentary imbalance, metabolism and the lack of physical exercise are potentially involved. Obesity represents a risk factor for a number of prevalent diseases associated with the metabolic effects of excess of adipose tissue, including coronary heart disease, hypertension, type 2 diabetes mellitus, and certain types of cancer. In the analyses carried out for the World Health Report 2002, approximately 58% of diabetes and 21% of ischemic heart disease globally were attributable to a BMI above 21 kg/m2. The health consequences range from increased risk of premature death, to serious chronic conditions that reduce the overall quality of life. This genetic test evaluates the effects of individual genetic variations in response to diet, exercise and lifestyle, all of which can cause the genes to be "expressed" in a positive or negative way. Nutrigenetic testing helps to identify inherited obesity risk (ADRB2, ADRB3, ANKK1, CLOCK, FTO, LEP, LEPR, MC4R, NPY, PLIN, TAS1R2, TNF, UCP2), carbohydrate sensitivity (ADRB2, KCNJ11, SLC2A2, SLC30A8, TCFL2), saturated fat sensitivity (ADRB2, APOA2, APOA5, APOC3, FABP2, FTO, LPL, PPARG, TNF), diabetes risk (ADRB2, APOC3, FABP2, FTO, KCNJ11, SLC2A2, SLC30A8, TCFL2) and exercise response (ADRB2, APOC3, LIPC, TCFL2). The nutrigenomic card provides genetic results and additional information that the patient needs to know in order to make informed modifications to their diet and lifestyle to improve their health and wellbeing. This study present allelic and genotyping frequencies of 26 SNPs analysed in the spanish population to determine their relevance as informative nutrigenomic biomarkers