8^th European Conference on Predictive, Preventive & Personalized Medicine and Molecular Diagnostics August 20-21, 2018 Rome, Italy

In personalized medicine  biomarkers and  biological marker  generally refers to a measurable indicator  of some biological state or condition. This word  refer to a substance the presence of which indicates the existence of a living organism. Biochemical biomarkers are often used in clinical trials, Biomarkers used for personalized medicine are typically categorized as either prognostic or predictive .In  , a biomarkers is a molecule that allows the detection and isolation of a particular cell type .  A biomarker indicates a change in  state of a protein that correlates with the risk or progression of a disease . Biomarkers are useful in a number of ways, including measuring the progress of disease. Biomarkers also used in  early diagnosis, disease prevention, drug target identification, drug response etc.

Personalized Medicine is a developing routine of medication that uses an individual's hereditary profile to guide choices made with respect to the counteractive action, determination, and treatment of ailment. Information of a patient's hereditary profile can offer specialists some assistance with selecting the best possible prescription or treatment and manage it utilizing the correct measurement or regimen. Utilized for the treatment as Personalized growth solution, Diabetes-related sickness: hazard appraisal and administration, Personalized pharmaceutical: New procedures and monetary ramifications, Implications of customized prescription in treatment of HIV, Applications of customized drug in uncommon illnesses, Translational Medicine.

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines.

Biological therapy refers to the use of medication , specifically target an immune or genetic mediator of disease. Even for diseases of unknown cause of  molecules that are involved in the disease process have been identified, and can be targeted for biological therapy. which are mainly cytokines , are directly involved in the immune system .Biological therapy used for the management of cancer , autoimmune disease, and diseases of unknown cause that result in symptoms due to immune related mechanisms.

Genetic disorders may or may not be heritable from the parents genes. In non-heritable genetic disorders, defects may be caused by new mutations  and changes to the DNA. In such cases, the defect will only be heritable if it occurs in the germ line .Such as some forms of cancer, may be caused by an inherited genetic condition in some people by new mutations in other people, and mainly by environmental causes in other people. Whether, when and to what extent a person with the genetic defect abnormality will actually suffer from the disease is almost always affected by the environmental factors and events in the persons development.

Personalized Medicine in Oncology is assigned to informing, educating, and fostering the exchange of clinically relevant information regarding the discovery and application of new Drug regimens, Molecular biomarkers, Cancer genomics, Molecular cancer  and Diagnostics in solid tumours and hematologic malignancies, as well as their impact on oncology care for patients. Over recent decades Cancer research has discovered a great and personalized medicine to cancer research and treatment

The proteome is the entire set of proteins it is expressed by genome , cell, tissue, or organism at a certain time. More specifically, it is a combined of proteins and genomes . Proteomics is the study of the proteome. A cellular  proteome is the collection of proteins present in a particular cell type and it exposure to harmone stimulation . It can also be useful to consider an organisms complete proteome, which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. Proteome used to refer to the collection of proteins in certain sub-cellular biological systems .

Pharmacogenomics is the study of  the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response, drug absorption distribution, metabolism, and elimination ,as well as drug receptor target effects . Pharmacogenomics isoften used interchangeably with pharmacogenetics. Pharmacogenomics is used for the detection of   the individual genetic variation with drug responses pharmacogenetics focuses on single drug-gene interactions, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.

The focus of Preventive Medicine and Public Health is health of individuals, communities, and defined populations. To, maintain health and protect, promote and to prevent disease, death and disability. The result of Public health surveillance is the identification and prioritization of public health issues the world is facing today, including HIV/AIDS, antibiotic resistance, diabetes, zoonotic diseases, and waterborne diseases. Preventive Medicine and Public health incorporates the interdisciplinary approaches of epidemiology, biostatistics and health services.

Metabolomics is defined as the chemical processes involving of  metabolites. Metabolomics is the  study of the unique chemical fingerprints. The metabolome refers to the collection of all metabolites in a biological cell, tissue, organ or organism. mRNA gene expression data and proteomic analyses reveals the set of gene products in the cell. One of the challenges of system biology and functional genomics  is to integrate proteomic ,transcriptomic, and metabolomic information to provide a cellular biology.

In personalized medicine molecular diagnostics is used for analysing of biological markers and also analysing by applying molecular biology to medical testing .This technique is used to diagnose and monitor disease,detect risk in individual patients .DNA sequencing is the process of determining the precise order of nucleotides within a DNA  molecule .SNP genotyping is the measurement of genetic variations of single nucleotide polymorphism (SNPs) . which is the measurement of more general genetic variation.Gene expression  profiling is used for the measurement of  the activity of thousands of genes at once.

Preventive medicine and Primary care includes disease prevention, health promotion counselling, health maintenance, diagnosis and treatment of acute and chronic illnesses, patient education, in a variety of health care. In healthcare system it provides advocacy to accomplish cost-effective care by cooperation of health care services. Primary care promotes effective communication with patients and encourages the role of the patient as a partner in health care.

Infection is invasion of an organisms , body tissues by disease causing agents their multiplication and the reaction of  host tissues to these organisms and they produced toxins . Infectious disease also known as transmissible disease and  communicable disease, is illness resulting from an infection.

Mental disorders are  psychological condition primarily by sufficient disorganization of  personality, mind, emotions to seriously impair the normal psychological condition. Mental disorders occasionally consist a combination of affective behavioural cognitive perceptual components. The acknowledgement of mental health conditions has changed over time and across cultures, and still observed variations in the definition,classification,and treatment of mental disorders.

Autoimmune diseases is damage a pathologic state arising from an abnormal immune response of the body against substances and tissues are normally present in the body. Autoimmunity is the presence of self-reactive immune response. (e.g., auto-antibodies and  self-reactive T-cells) with or without damage or pathology resulting from it.

 Vascular Surgery is a surgical subspecialty in which diseases of the vascular system, arteries and veins, are managed by medical therapy. The specialty evolved from general and cardiac surgery and also minimally invasive techniques pioneered by interventional radiology. The vascular surgeon is trained in the diagnosis and management of diseases affecting all parts of the vascular system except those of the heart and brain. Cardiothoracic surgeons and cardiologists manage disease of vessels of the heart. Neurosurgeons and interventional Neuron radiologists manage surgical disease of the vessels in the brain.

Endovascular aneurysm repair (or endovascular aortic repair) (EVAR) is a type of endovascular surgery used to treat the pathology of aorta. When used to treat thoracic aortic disease, the procedure is then specifically termed TEVAR (thoracic endovascular aortic/aneurysm repair). The process involves the placement of an expandable stent graft within the aorta to treat aortic disease without operating directly on the aorta

Personalized medicine is a Medical Practice that separates patients into different groups with medical decisions, practices, interventions and  products being tailored to the individual patient based on their predicted response or risk of disease. The words of  personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably.

Medical ethics is a system of moral principles that apply values and judgments to medical practice. As a scholarly discipline, medical ethics encompasse its application in clinical settings as well as work on its history, philosophy, and sociology.

A comprehensive, personalized approach to medicine is required to promote the safety of therapeutics and reduce the cost of chronic disease. Personalized lifestyle medicine may provide a novel means of addressing a patient's health by empowering them with information they need to regain control of their health

A neurological disorder is any disorder r of the body nervous system. Structural, biochemical or electrical abnormalities of brain, spinal cord or other nerves can result in a range of symptoms. The symptoms include paralysis, muscle weakness , loss of sensation,seizures confusion pain and altered levels of consciousness.They may be assessed by neurological examination, studied and treated within the specialities of nuerology and clinical neuropsychology.