Ghulam Rasool Mashori
Peoples University of Medical & Health Sciences for Women
Title: Effects of Nifedipine An Antihypertensive Drug on Glucose and Epinephrine.
Biography
Biography: Ghulam Rasool Mashori
Abstract
Hypertension, hyperlipidemia, Hyperglycemia and Cigarette smoking are major risk factors for the development of Coronary Heart Diseases (Newcomer & Hennekens, 2007). Hypertension is the leading curable risk factor for cardiovascular disease, affecting more than 1 billion people worldwide (Patel et. al 2016). Treatment of hypertension is to reduce future cardiovascular morbidity and early death. Antihypertensive therapy has shown improvement in the incidences of stroke, heart failure & renal failure however, the incidence of CHD has not been reduced to that degree (The Sprint Research Group, 2017). Normal human BP (Systolic/Diastolic) ranges from 120/80mmHg to 140/90mmHg. Hypertension is the continuous elevation of resting systolic ≥140mmHg & diastolic ≥90mmHg BP (Carretero & Operil, 2000). Effects of Nifedipine an antihypertensive drug were seen on Glucose, Insulin & Epinephrine, in the light of Helsinki Criteria, a study designed on nondiabetic and diabetic hypertensive patients. Two sets, minimum of 12 patients (6-non-diabetics and 6-diabetics) were recruited for treatment. In Set-A non-diabetic hypertensive patients were kept on placebo first for two weeks and GTT was performed, then patients switched on Nifedipine at an average dose 23.8±7.4mg/day. When the diastolic BP normalized ≤90mmHg at-least for 6-weeks period, then second GTT was performed. In Set-B, diabetic hypertensive patients treated with Nifedipine first at an average dose 21.3±3.5mg/day for 6-weeks period, GTT was conducted, followed by a placebo period for 2-weeks then the patients went through second GTT for quantifying glucose, insulin and catecholamine blood levels and results were compared. Based on results it is concluded that, Nifedipine worsens Glucose Tolerance and it is a diabetogenic drug.