Sergey Suchkov
First Moscow State Medical University, Russia
Title: PPPM as a sort of National and International Models of Healthcare Services of the Newest Generation: The Invitation for the Innovations to Secure the Biosafety of the Nations
Biography
Biography: Sergey Suchkov
Abstract
The medicine is undergoing a paradigm shift to strive from the diagnosis and treatment for prediction and prevention. And, for sure, any innovations in healthcare services are an important driver to move the new trend forward. A ISPM, Tokyo, Japannew systems approach to disease to pay its crucial attention on the trend would result in a new branch in the healthcare services, namely, predictive, preventive and personalized medicine (PPPM). The latter is defined as: “…the capacity to predict the development of disorder-related signs and influence decisions about lifestyle choices or to tailor medical practice to an individual…”
All chronic disorders develop gradually over a period of time to take years for a process to reach a level where it could be diagnosed definitively and treatment initiated properly and in time before changes are irreversible! And, for example, Parkinson’s costs society $27 billion per year in medical bills and lost wages; worldwide, projected cases of Parkinson’s will more than double by 2030!
To achieve the practical implementation of PPPM concept, it is necessary to create a fundamentally new strategy based upon the subclinical recognition of biopredictors of hidden abnormalities long before the disease clinically manifests itself. This strategy would give a real opportunity to secure preventive measures whose personalization could have a significant influence on demographics!
Two key objectives of PPPM are: (i) detection of subclinical abnormalities based on the biomarkers validated with a selection of suitable targets for the next step of PPPM protocol, i.e., drug-based prevention; (ii) drug-based correction of the abnormalities detected under the heading of preventive measures. PPPM is thus a medical model being tailored to the individual and dictates a construction of PPPM algorithms to diagnose, to predict, and to prevent in time!
The key benefits of PPPM include new abilities:
(i) to detect disease at a subclinical stage, when it is easier and less expensive to treat effectively;
(ii) to stratify patients into groups that enable the selection of optimal preventive treatment;
(iii) to reduce adverse drug effects by more effective early assessment of individual drug responses;
(iv) to improve the selection of new molecular targets for drug discovery;
(v) to shift the emphasis from illness to wellness.
PPPM-motivated patients or persons at risk become data carriers, and the physician can reasonably select of preventive protocol, proceeding from the assays made. It would be extremely useful to integrate data harvesting from different databanks for applications such as prediction and personalization of further treatment. The practitioners will be able to thus provide more tailored prevention and treatment programs for their patients resulting in improved patient outcomes, reduced adverse events, and more cost effective use of health care resources. Pharmacogenomics can help to inform a tailored dosage regimen allowing for an improved drug response, while managing the risk adverse reactions.
PPPM is not an incremental innovation…. It is a radically new stage in the way medical services are delivered and diseases or treatments understood. In addition to the promise of improved patient care and disease prevention, there is potential for PPPM to impact on the cost of health care. Let me just comment that equally important is a PPPM-related test’s clinical utility, both in terms of its health and economic implications, when compared to standard healthcare.
Implementation of PPPM requires a lot before the current model “physician-patient” could be gradually displaced by a new model “medical advisor-healthy men-at-risk”. This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPPM to elicit the content of the new branch. What is a realistic timeline for the incorporation of PPPM into the practice? The idea raises many critical questions that must be answered before data from basic research can be routinely incorporated into the daily healthcare delivery. So, coordinated measures to optimize the progress should be well-focused on solving the accumulating problems in healthcare and the concomitant economic burden that societies across the globe are facing more and more.