Sadhana Shrivastava
Jiwaji University, India
Title: Reversal of acryl amide-induced toxicity by kaempferol therapy in rats
Biography
Biography: Sadhana Shrivastava
Abstract
Kaempferol is a natural fl avonol, a type of fl avonoid that has been isolated from broccoli, grapefruit, cabbage, tomato, grapes and apples. Acryl amide (AA) is an industrial chemical with neurotoxic, carcinogenic eff ects in humans and has been known as an occupational hazard for decades. However, in recent years, AA has been found to form in fried and baked starchy foods like potato chips, French fries etc during cooking. Th e aim of the present study was to evaluate the therapeutic effi cacy of Kaempferol against AA induced toxicity in rats. AA was administered at the dose of 19.13 mg/Kg for 28 days to albino rats followed by therapy with 20 mg/ Kg dose of Kaempferol. Th e various toxicity symptoms were observed which include signifi cant reduction of body weight, hair loss, hind-limb splaying, dragging of back legs and irritation on skin. Th ere was signifi cant elevation in the level of AST, ALT and ALPase with reduction in levels of hemoglobin and blood ALAD and ALAS in brain aft er AA exposure. Activities of acetyl cholisterase, GST, GR and GPx were also declined in AA treated groups as compared to control group. Aft er AA intoxication, activities of drug metabolizing enzymes (AH, AND, CYT P-450) were depleted with increase in G-6-PDH, microsomal lipid peroxidation and also induced DNA damage. Histo-pathological observations also supported biochemical studies. Kaempferol has a therapeutic potential for the protection of AA induced toxicity to prevent harmful eff ects