Sangeeta Shukla
Jiwaji University, India
Title: Modulatory Effects of micronutrients on metal toxicity
Biography
Biography: Sangeeta Shukla
Abstract
There is growing evidence that micronutrient intake has a signifi cant eff ect on the toxicity and carcinogenesis caused byrnvarious metals. In our study we examine the eff ect of micronutrient status (Zn, Ca, Fe and Se) on the toxicity of metalsrnlead, mercury, and aluminium.rnWe have studied therapeutic potential of micronutrients selenium, zinc, calcium, iron against heavy metal alone andrncombination with chelating agents. We have chosen to separate the eff ect of micronutrients on toxic metals into threernclasses: interaction between essential micronutrients and toxic metals during uptake, binding, and excretion; infl uence ofrnmicronutrients on the metabolism of toxic metals; and eff ect of micronutrients on secondary toxic eff ects of metals. Based onrndata from mechanistic studies, the ability of micronutrients to modulate the toxicity of metals is indisputable. Micronutrientsrninteract with toxic metals at several points in the body: absorption and excretion of toxic metals; transport of metals in thernbody; binding to target proteins; metabolism and sequestration of toxic metals; and fi nally, in secondary mechanisms of toxicityrnsuch as oxidative stress. Th erefore, people eating a diet deficient in micronutrients will be prone to toxicity from metals