Noha Amer
Cairo, Egypt
Title: Cholesterol Ester Transfer Protein (CETP) Taq IB polymorphism in Egyptian patients with acute coronary syndromes
Biography
Biography: Noha Amer
Abstract
Background: Taq IB polymorphic site of the CETP gene has been studied for a possible relation to the development of cardiovascular diseases in some ethnic groups. So far there are no data concerning the CETP Taq IB polymorphism in Egyptians. Our study aimed to investigate the frequency of different CETP Taq IB polymorphism genotypes in Egyptian acute coronary syndrome (ACS) patients and healthy controls and investigate whether this polymorphism predisposes to ACS. Methods: The Current study was conducted on 70 hospitalized patients with ACS and 30 control subjects which are age and sex matched to the patients. The patients were subdivided into two groups: MI group: 40 patients with myocardial infarction and UA group: 30 patients with unstable angina. CETP Taq IB genotyping was determined using TaqMan real time PCR. Results: The CETP genotype frequencies were: 42.86%, 44.28% and 12.86% in all patients, 30%, 60% and 10% in MI patients, 60%, 23.33% and 16.67% in UA group, 30%, 53.33% and 16.67% in controls for GG, GA and AA genotypes respectively. The frequency of GA genotype was significantly lower in UA patients than that in the control group (P<0.05). Conclusions: The frequency of CETP Taq IB genotypes and alleles in Egyptian ACS patients and healthy controls was similar to that in other ethnic groups with GA genotype was the most common genotype and G allele was the major allele. Taq IB GA genotype carriers may have lower risk of UA.