Reda Mohamed Elbadawy
Banha University Faculty of Medicine, Egypt
Title: Cardiovascular manifestations of Non-Alcoholic Fatty liver can be prevented?
Biography
Biography: Reda Mohamed Elbadawy
Abstract
The relation between Non –Alcoholic liver disease(NAFLD) and cardiovascular diseases (CVD)has not been elucidated with non diabetic obese normal healthy subjects. Th e aim: Was to evaluate the use of simple biomarkers as predictors for NAFLD and consequanly CVD. Seventy seven Subjects divided into two groups: Group( 1) included 37 patients known to have diabetes mellitus type 2 , Group( 2) included 40 healthy subjects who have no medical illness. Results: Th ere was a statistical signifi cant diff erence for all laboratory parameters between the 2 groups except for total bilirubin, direct bilirubin and ALT/AST ratio. In DM group fatty liver was diagnosed in 22/37(54%) by abdominal ultrasound. Th e median values of TG, insulin, leptin, insulin resistant, ALT ,GGT,AST and ALT/AST ratio in diabetic patients were statistically signifi cant higher in those with fatty liver compared with those without fatty liver (P values <0.05). In group 2 fatty liver was diagnosed by abdominal ultrasound in 12/40( 30%). Th e median values of FBS,TG, cholesterol, insulin, leptin, insulin resistant, ALT ,GGT,AST and ALT/AST ratio in the healthy subjects were statistically signifi cant higher in those with fatty liver compared with those without fatty liver (P values <0.05).Th e sensitivity and specifi city of GGT, ALT/AST ratio was as follow 100.%, 59% and 73%, 55% at a cut off value of 45 IU/l and 1.9 respectively. Conclusion: Elevated liver enzymes, although in normal ranges, play a role in early diagnosis of fatty liver disease which has a predict for the presence of cardiovascular diseases especially carotid intimal thickning